Dosage,Safety and Suggestions.
Dosage,Safety and Suggestions.:
How Much Goldenseal Should I Supplement?:
As a dietary supplement, 500mg of Golden Seal is used 2-3 times daily; higher amounts are used at the onset of symptoms of the above conditions, as both Echinacea and Goldenseal will inhibit the effectiveness of hyaluronidase, an enzyme secreted by microbes to dissolve mucous membranes and thusly gain entry into your body.
A typical dose of goldenseal is 250mg to 500mg three times per day. It can also be used topically in creams and ointments to heal skin wounds.Goldenseal herbal tincture can be used as a mouthwash or gargle for mouth sores and sore throats. A tea made of goldenseal can also be used for this purpose, made by boiling 0.5 g to 1 g in a cup of water.
Most people take 4-6 grams of powdered goldenseal root and rhizome supplements per day as tablets or capsules.For liquid herbal extracts, 4-6 ml are used.
Continuous use should not exceed three weeks, with a break of at least two weeks between use. Goldenseal powder as a tea or tincture may soothe a sore throat.
Capsules or tablets: 500 - 2,000 mg, up to 3 times daily
Standardized extract: 30 - 120 mg, up to 3 times daily
Tinctures (1:5): 3 - 7 mL, daily
For disinfecting cuts, scrapes, boils, and acne: Place goldenseal liquid extract on a clean cloth, and press the cloth gently on the affected area.
For earaches: Mix with olive oil and use as eardrops.
For sore throat, gums, or mouth, make a mouthwash as follows: In one cup of warm water, mix 1/4 tsp salt and 1/2 tsp (or the contents of one capsule) of goldenseal powder. (It will not dissolve completely.) Rinse and expectorate (spit out).
For vaginal irritation, make a goldenseal douche as follows: Mix 1/4 tsp salt and 1/2 tsp (or the contents of one capsule) of goldenseal powder in 1 cup of warm water. Let the mixture settle, and strain out any suspended particles before using it. (Keep the mixture as clean as you can.) Over-douching can make you more susceptible to certain kinds of vaginal infections. See your health care provider if your symptoms do not improve after a few days.
For eye infections and irritations, make an eyewash as follows: Use one cup of sterile water with 1/4 tsp salt and 1/2 tsp goldenseal (or the contents of one capsule), and strain out all particles. Discard if the solution becomes cloudy, which indicates bacterial growth or spoilage.
Pediatric Dosage: Adjust the recommended adult dose to account for the child's weight. Most herbal dosages for adults are calculated on the basis of a 150 lb (70 kg) adult. Therefore, if the child weighs 50 lb (20 - 25 kg), the appropriate dose of goldenseal for this child would be 1/3 of the adult dosage.
Goldenseal contains hydrastine and berberine which give it antibiotic, anti-inflammatory, alternative laxative and tonic properties. It has been traditionally used for such ailments as eye inflammations, cancer, high blood pressure, skin and liver diseases.
The thick yellow root of this herb was originally used by the Cherokees, a Native American tribe, as a tonic for indigestion and in the treatment of cancer; other Native American tribes used it for liver disorders, fevers, and heart problems. The remedy was proved in 1875 by Dr. Hale, an American homeopath.
Ailments of the mucous membranes, such as phlegm, sinus congestion, sore throats, and taste disorders are treated with this remedy. Hydrastis is also used for stomach complaints in which digestion is weak and characteristically the stomach feels empty but is not relieved by eating. There may be constipation without urging. This remedy is useful for people who have suffered weight loss due to chronic degenerative diseases.
Safety of Goldenseal:
Taken as recommended, goldenseal is generally safe. However, as with all alkaloid-containing plants, high amounts may lead to gastrointestinal distress and possible nervous system effects. Goldenseal is not recommended for pregnant or lactating women.
Goldenseal herbal safety...some possible adverse effects of goldenseal include but are not limited to: nausea and diarrhea. Consuming the plant fresh (as opposed to an herbal supplement form) can irritate mucous tissues and possibly cause respiratory problems.
Goldenseal should not be taken continuously. Some herbalists believe you should only take it when you're coming down with a cold, flu, or illness; while others suggest that it be cycled by taking it for three weeks and then discontinued for the same length of time, etc.
Do not use continuously for more than 1 week without consulting a physician.
Pregnant or nursing women, as always, should refrain from using goldenseal root.
In addition, if you have high blood pressure, diabetes, heart disease, or glaucoma, make sure you avoid this herb...the effects of goldenseal are such that it may increase blood pressure.
It is possible there are other issues with goldenseal herbal safety, so make sure you always speak with your physician before taking supplements or herbal remedies of any kind, especially if you have an existing medical condition.
Goldenseal Root is an herb that has been used for centuries as a natural antibiotic to fight infections, particularly of the mucous membranes including conjunctivitis. Clinical trials demonstrate conclusively that goldenseal kills many harmful bacteria. The golden, yellow root of this plant gives it its name. Goldenseal Root has antibiotic properties stronger than many prescription medicines and is able to target "unwanted" bacteria, as well as protozoa and yeasts. Goldenseal Root is unique in that it does not harm the "beneficial" bacteria that are necessary in the digestive tract. The alkaloid berberine has the added benefit of increasing blood flow through the spleen, where it also increases the immune-building activity of the large supply of white blood cells there. By many herbalists Goldenseal Root is considered one of the most powerful herbs. It is a substitute for quinine. Goldenseal Root is one of the most effective remedies for inflamed and catarrhal conditions of the mucus membranes. Goldenseal Root has the ability to heal mucus membranes anywhere in the body (bronchial tubes, throat, intestines, stomach, etc.).
Caution and Precautions:
Small children and pregnant and nursing Women should only use this herbal remedy under the guidance of a physician.Those with hypoglycemia should avoid taking the root internally, but can safely use it as a mouthwash, eyewash or douche. Pregnant women should avoid using goldenseal until they have delivered. It should also not be used for more than two months at a time as it can interfere with the colon's ability to manufacture vitamin B.It is inappropriate for newborn babies.
The use of herbs is a time-honored approach to strengthening the body and treating disease. Herbs, however, contain components that can trigger side effects and interact with other herbs, supplements, or medications. For these reasons, herbs should be taken with care, under the supervision of a health care provider qualified in the field of botanical medicine.
Pregnant or breastfeeding women as well as those with high blood pressure should avoid using goldenseal. Pregnant or nursing women should not use Goldenseal nor any other herb containing berberine. Goldenseal may limit the efficacy of anticoagulants (aspirin, blood thinners, Coumadin, etc.), and may also interfere with tetracycline antibiotics. Excessive use (many times the recommended dosage) may cause vomiting, diarrhea, diarrhea, lethargy, skin, eye or kidney irritation, nosebleed, lowered blood pressure and lowered heart rate. Because Goldenseal may lower blood sugars, people with diabetes should use it only under the supervision of a physician. Do not use Goldenseal if you have a glucose-6-phosphate dehydrogenase deficiency without consulting a doctor. Those who suffer hyperthyroid conditions, high blood pressure or epilepsy should avoid this product. Goldenseal should not be taken for prolonged periods; it can be poisonous if used too much.
Goldenseal can irritate the skin, mouth, throat, and vagina. It can also reduce the number of "good" bacteria in the digestive system, which can cause nausea and diarrhea. Goldenseal may also cause an increased sensitivity to sunlight.
Goldenseal may interfere with the metabolism and effectiveness of certain medications. Do not use goldenseal if you are taking prescription or non-prescription medications unless you are under the supervision of a qualified health care provider.
Pregnant women should avoid goldenseal because of evidence that it can stimulate uterine contractions in animals.People with heart conditions, bleeding abnormalities, and epilepsy are advised to avoid goldenseal because of its potential to cause serious adverse reactions.Despite its history as an eyewash, goldenseal solution should not be placed in the eyes.
Who Should Consider Goldenseal:For What Is Goldenseal Used?
Famous for use against sore throat and Strep throat
High in berberines, Goldenseal is a powerful anti-inflammatory and antibiotic specific for mucous membrane infection, sore throat, gastritis, colitis, or cleansing. Externally it may be used as a wash for eye infection, skin infection, vaginitis.
Effective against bladder infections
Effective against protozoa, bacteria, and fungi, including Candida albicans
Side Effects of Goldenseal:
Goldenseal contains berberine, a mild oxytocic (stimulates contractions of the uterus) and should not be used by pregnant women. Goldenseal is contraindicated in pregnancy and hypertension; adverse effects with normal doses are rare.Otherwise there are none.
A few studies report interactions between berberine (a major component of goldenseal) and prescription or non-prescription medicines. One study reported that berberine may decrease the effectiveness of tetracycline antibiotics. Other laboratory studies report that berberine may alter liver metabolism, potentially affecting the levels of medications processed in the liver. Several studies actually report that goldenseal itself does not interact with medicines metabolized by the liver (including an antiviral drug used in HIV infection and digoxin). However, if you are taking prescription or non-prescription medications, do not use goldenseal unless you are under the supervision of a qualified health care provider.
The herb is recommended in chronic respiratory tract infections, however, it is not traditionally recommended in acute respiratory tract infections. In other words, if you have a cough or a cold, do not use it. It should be reserved for those with ongoing problems with their respiratory tract and specifically when this includes chronic overproduction of mucous. Chronic sinusitis, rhinitis, tonsillitis, and bronchitis are examples of conditions where it helps. Chronic hay fever is another instance where it can make a real difference. When the mucous membranes just pump out mucous unnecessarily, it can be used to good effect. People who sound like they have corks stuck in their nostrils are good examples of people benefited by its use.
However, having said that, herbal medicine is about getting to the root of the problem. More often than not, there is a simple thing one can do to get these mucous membrane inflammations to go away. A little known but common cause of respiratory ills is the consumption of dairy products. If you really are tired of having chronic respiratory infections, remove all dairy products from your diet. You see, the minute you take them into your body, your mucous membranes start pumping out mucus. If your sinuses don't drain well, that mucus is going to get stuck in them, and you know what comes next. The same is true for all respiratory conditions build on mucous over production. They are made worse by the consumption of dairy products. We have seen hundreds of patients whose condition disappears when they abstain from dairy products. Get rid of the dairy, you may need nothing else.
Very high doses of goldenseal may rarely induce nausea, anxiety, depression, seizures, or paralysis. Hydrastine was once used as a uterine hemostatic, but was found inferior to ergot in the treatment of postpartum hemorrhage. Goldenseal is generally contraindicated for use in pregnancy. Because of hypenensive actions of the alkaloids, it is also contraindicated in cardiovascular patients.
To avoid toxicity do not take large doses of goldenseal. Regular use should not exceed three weeks. Do not give goldenseal to children or pregnant women. Nausea and diarrhea are among goldenseals negative side effects as well as anxiety, stomach cramps, and vomiting. In extreme cases respiratory depression, heart murmurs, or paralysis may occur. These more dangerous results are very rare.
Do not combine goldenseal with blood thinners, alcohol, or beta blockers.
How it works and the mechanism:
The isoquinoline alkaloids are thought to be largely responsible for goldenseal's medicinal actions, the hydrastine acting as an astringent and as a hemostatic agent (stops bleeding). The berberine has both antibacterial and amoebicidal properties, while the canadine is thought to stimulate the uterine muscles. Goldenseal's main use is in the treatment of mucous membranes throughout the body. Goldenseal is used in the respiratory system for conditions of excess mucus and also for the eyes, nose, and throat where inflammation is present. Its antibacterial properties make it useful for infection, especially in the mouth or eyes. Used for short periods of time as a tonic it can increase appetite and stimulate the digestion. In the reproductive system goldenseal alleviates heavy bleeding and astringes the membranes where there is vaginal infection.
Influence of goldenseal root on the pharmacokinetics of indinavir:
Goldenseal root was identified as the most potent inhibitor of CYP3A4 in a study that tested 21 popular herbal products for in vitro inhibitory activity.
The purpose of this investigation was to examine the influence of goldenseal root on the disposition of the CYP3A4 substrate indinavir in humans. Using a crossover study design, the pharmacokinetics of indinavir were characterized in 10 healthy volunteers before and after 14 days of treatment with goldenseal root (1140 mg twice daily). Indinavir was given as a single 800-mg oral dose, and blood samples were collected for 8 hours following the dose.
No statistically significant differences in peak concentration (11.6 vs. 11.9 mg/L) or oral clearance (26.8 vs. 23.9 mg*h/L) were observed following treatment with goldenseal root. Half-life and time to reach peak concentration were also unchanged by goldenseal.
These results suggest that patients being treated with indinavir can safely take goldenseal root and that interactions with other drugs metabolized by CYP3A4 in the liver are unlikely.
- 1.Goldenseal Root,Echinacea's partner, broad-spectrum herbs and its uses.
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