Larch Larix occidentalis and Arabinogalactan:Anti-Metastatic and Immune Stimulant natural source.

article content dotArticle Content:

Pharmacological Properties of ABG-Arabinogalactan.

Western Larch Extract D-Arabinogalacatan Arabinogalactan Extract CAS 9036-66-2 Larix occidentalis Nutt L-arabinofuranose unit or 3-O-(beta-L-arabinopyranosyl)-alfa-L-arabinofuranosyl units photo picture image strong immunostimulating properties, with anti-inflammatory and anti-allergy properties, (low to molecular weight polysaccharides 5,000-15,000)

 enhances carbon and other toxins clearance by the macrophages (medium molecular weight polysaccharides 15,000-50,000)

 stimulates the immune function in a non-specific (broad spectrum) manner (high molecular weight polysaccharides 75,000-125,000)

 enhances natural killer cytotoxicity
 prevented tumor cell colonization of the liver in laboratory animals
 may be used as a carrier molecule for hepatocyte directed drug delivery
 broad spectrum defense against bacterial, viral, and fungal pathogens
 shows promise in the treatment of HIV and malignant tumors
 as an adjunct to cancer therapy

 increases colonic butyrate and decreases colonic ammonia concentrations, so arabinogalactans may be an preferable form of fiber supplementation

 plays a major role as a modulator of the immune system

 Pharmacokinetics:

 Reviewed data suggested that following the ingestion of arabinogalactan,its gastrointestinal absorption will be negligible (less than 1%).Arabinogalactan is a non-digestible soluble dietary fibre that resist hydrolytic enzyme action and enters the large bowel intact where it is fermented by human intestinal bacteria.It is fermented at a slower rate than other polysaccharides because of its branched structure,but bacterial enzymes necessary for its degradation are inducible.The outcome of fermentation is the production of SCFAs,principally acetate,propionate and butyrate,gases(carbon dioxide,hydrogen and methane) and bacterial cell mass.The SCFAs are directly absorbed at the site of production and may be metabolised either locally in the colonic wall,by the liver or by peripheral tissues for maintenance,growth or lipogenesis.All these metabolic processes are relatively well understood,and limited supplementation with,or increased dietary load of,arabinogalactan is unlikely to pose any unusual or excessive metabolic challenge in the human body.

Last PageNext Page

Reference:

citations1.Larch Larix occidentalis and Arabinogalactan:Anti-Metastatic and Immune Stimulant natural source.

last edit date:20th,June.2009.