Coleus Forskohlii and Forskolin Mechanism of action.

Applications and Properties:

Applications:

Weight management.
Lean body mass.
Effects on Cyclic AMP.
Glaucoma.
Asthma and Allergies.
Hypothyroidism.
Cancer Metastases.
Immune Enhancement.
Psoriasis.
Cardiovascular Disease.
Stimulate Thyroid Hormone Production/Increase Metabolism.

Properties:

Coleus Forskohlii is a member of the mint family and is recognized in the world of herbal medicine as the only plant source of the diterpene compound known as forskolin. What makes forskolin so important is its ability to stimulate the synthesis of cyclic AMP, which among other outcomes, triggers the release of fat from fat cells and speeds up metabolism by increasing thermogenesis (the rate at which the body burns calories at rest, emitting it as heat to the environment.) The other agent known to produce a similar effect is ephedrine and its adrenaline-like sister compounds, which are known to have dangerous side effects. Unlike ephedrine, forskolin does not stimulate the nervous system. It is able to increase the release of stored fats, elevate metabolism and increase lean mass by increasing the synthesis of cyclic AMP, without stimulating the central nervous system. Thus, forskolin give you all the fat-burning benefits as ephedrine without the risks or side effects.
Dosage:15% forskolin recommended taking 50-100 mg of standardized coleus extract two to three times per day.

Safety and Toxicity:

The LD 50 value of Coleus forskohlii 10% in rats by oral route was found to be greater than 2000mg/kg body weight.There isn't much research on Coleus forskohlii's safety, but so far it hasn't caused any adverse reactions in people.If you are pregnant or nursing, though, forskolin is not recommended.