Coleus Forskohlii and Forskolin Mechanism of action.

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Basic Botanical Data of Coleus Forskohlii.

Coleus Forskohlii Extract CAS 66575-29-9 66428-89-5 photo picture image Coleus Forskohlii
 Botanical name:Coleus forskohlii
 Latin Name:Coleus Forskholii
 Family:Labiatae(Lamiaceae,Mint)
 Common name:Makandi,Sanskrit
 Part used :Root,Raw root powders may have 0.2 to 0.3% forskolin.
 Origin and Habitat: A perennial plant which grows widely spread from YunNan Province of China(Dong Chuan), to other areas including Indian plains,Sri Lanka,Nepal,Bhutan,Thailand and North Africa
 History: It is also been grown as an ornamental and root is used as a spice.
 Tradition: It has been used in India as an Ayurvedic herb
 Parts used and where grown: This attractive, perennial member of the mint (Lamiaceae) family originated in the lower elevations of India. It is now grown around the world as an ornamental plant. The root is used medicinally.
 Coleus Forskohlii Extract CAS 66575-29-9 66428-89-5 photo picture image

 Basic Description:

 Coleus Forskohlii Extract is produced from the root of Coleus forskohlii, an ancient Ayurvedic plant. Coleus is the source of a unique substance known as forskolin, which nutritionally supports the increase of cyclic-AMP. Cyclic-AMP is involved in many of the body's cellular reactions.This extract is analyzed and guaranteed to contain a minimum of 18% forskolin.

 Coleus Forskohlii is an important traditional Ayurvedic herb that has been a part of Indian medicine for centuries. In the 1970s, researchers isolated a chemically active ingredient in the herb and called it forskolin.

 Coleus Forskohli is a perennial member of the mint (Lamiaceae) family that was first discovered in the lower elevations of India. It is now grown around the world as an ornamental plant. The root is used for a myriad of medicinal purposes. As recorded in ancient Sanskrit texts, coleus has been used as a medical herb to treat heart and lung diseases, intestinal spasms, insomnia, and convulsions.

 Forskolin is a chemical found in the coleus herb that activates the enzyme adenylate cyclase. Andenylate cyclase compound initiates a myriad of critical events and processes within all the cells of the human body. Adenylate cyclase and the chemicals it activates comprise are responsible for executing a number of important hormonal processes. Stimulation that is caused by forskolin suppossedly leads to blood vessel dilation, inhibition of allergic reactions, and possibly an increase secretion of thyroid hormone. Forskolin has other reported uses as well, including inhibition of the pro-inflammatory substance known as platelet-activating factor (PAF)6 and inhibition of the spread of cancer cells.

 Some studies in humans have shown that direct application of a special preparation of forskolin to the eyes lowers eye pressure, whereby decreasing the risk of glaucoma. Direct application of the whole herb to the eyes has not been studied and is not recommended by any medical professionals that we know of.

 It has been reported that forskolin may may also assist in dilating blood vessels and improving the forcefulness with which the heart pumps blood. Some studies have indicated that forskolin may help to reduce blood pressure and improved heart function in people with cardiomyopathy. However, there is no clear evidence as to whether or not oral supplementation with coleus extracts would be an effectient of way of taking this herb. One study did find evidence that inhaling forskolin could decrease lung spasms for people with asthma.

 Historical or traditional use (may or may not be supported by scientific studies): As recorded in ancient Sanskrit texts, coleus was used in Ayurvedic medicine1 to treat heart and lung diseases, intestinal spasms, insomnia, and convulsions.

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Reference:

citations1.Coleus Forskohlii and Forskolin Mechanism of action.

last edit date:20th,June.2009.