Coleus Forskohlii and Forskolin Mechanism of action.

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Phytochemistry of Forskohlin.

Coleus Forskohlii Extract CAS 66575-29-9 66428-89-5 photo picture image Forskolin:

 Synonyms: 7beta-Acetoxy-8,13-epoxy-1alpha,6beta,9alpha-trihydroxylabd-14-en-11-one;Coleonol;Colforsin.

 Molecular Formula:C22H34O7;Molecular Weight:410.50

 CAS RN:66575-29-9 Beilstein RN:1692716 EG/EC Number 2664109 MDL number MFCD00082317 PubChem Substance ID 24278035.

 Solubility DMSO: 5 mg/mL stable at least 6 months at room temperature/ethanol: soluble

 Forskolin, is a cell permeable diterpenoid isolated from Coleus forskohlii. Forskolin has a unique ability to stimulate adenylate cyclase activity and increase intracellular cyclic adenosine monophosphate (cAMP) thus activating cAMP-dependent protein kinase and other cAMP receptor proteins.

 Molecular weight 410.5 g/mol. Solubility: Soluble in anhydrous DMSO, acid ethyl ester or 100% ethanol. Purity: >98% (HPLC). Formula C22H34O7.

 Biochem/physiol Actions:Cell-permeable diterpenoid that possesses anti-hypertensive, positive inotropic, and adenylyl cyclase activating properties. Many of its biological effects are due to its activation of adenylyl cyclase and the resulting increase in intracellular cAMP concentration.1 Forskolin effects calcium currents and inhibits MAP kinase.

 Forskolin ( 7beta-acetoxy-8,13-epoxy-1a,6beta,9alpha-trihydroxylabd- 14-en11-one) is a diterpenoid compound which directly activates adenylate cyclase.

 Forskolin may also have a modulating effect on thyroid function as it has been shown to have a mild thyroid stimulating action, which may also help to explain its effectiveness in helping overweight subjects increase their metabolism and thermogenic activity. It is thought that many overweight patients with slow metabolisms may suffer from a sub-clinical, under active thyroid problem that is not detectable using standard blood tests. Supplementation with coleus forskolin may help to overcome that barrier to weight loss in concert with its other fat-burning properties. Forskolin is an extremely safe and non-toxic supplement that can be used to aid in body fat reduction and lean mass gains.

 Other Phytochemicals: diterpenoids, deacetylforskolin, 9-deoxyforskolin, 1,9-deoxyforskolin, 1,9-dideoxy-7-deacetylforskolin, along with four minor diterpenoids have also been reported to be present in the roots of Coleus forskohlii.

 The diterpene forskolin, derived from the root of the plant, is the primary constituent of clinical interest in Coleusforskohlii.It was discovered by Western scientists in 1974 and was initially referred to as coleonol. Since that time, as other coleonols and diterpenoids have been identified, the name was changed to forskolin. Forskolin is responsible for virtually all pharmacological activities attributed to Coleus forskohlii; extracts of this constituent have been used in nearly all existing studies. There is evidence, however, that other plant constituents, such as volatile oils and other diterpenoids and coleonols, may contribute to the pharmacological activity and absorption of forskolin.Detailed analysis reveals approximately 20 constituents in various parts of the plant, but forskolin and other coleonols are present only in the root portion.

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Reference:

citations1.Coleus Forskohlii and Forskolin Mechanism of action.

last edit date:20th,June.2009.