Feverfew,Dioscorides's Fever Reducer or febrifugia,what is the history of this pretty daisy-like flower?

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How FeverFew works in the body and Mechanism.

Feverfew Extract INCI Name Chrysanthemum Parthenium Extract CAS 89997-65-9 EINECS ELINCS No 289-701-2 Tanacetum parthenium photo picture image Feverfew's action against fevers is thought to be due to the sesquiterpene lactones, which inhibit the release of arachidonic acid in the body. These ingredients have also been shown to inhibit other substances which contribute to antiblood clotting. In the reproductive system, feverfew has an age-old function of promoting menstrual flow. Its main use today is to prevent and alleviate headaches, especially migraine. Feverfew is thought from research that the sesquiterpene lactones, among the other constituents, inhibit the secretion of serotonin, which is implicated in the onset of migraine. Another area of research is looking at the role feverfew has in the musculoskeletal system, where its inhibitory effects are thought to help control pain in conditions such as arthritis.

 Inhibits cellular phospholipases, which prevents release of arachidonic acid from cell membranes for the production of inflammatory prostaglandins and leukotrienes:

 "Inhibits uptake as well as liberation of arachidonic acid (AA) into/from platelet membrane phospholipids (PL)."
 Flavonol and flavone methyl ethers inhibit the major pathways of arachidonate metabolism in leukocytes in vitro.
 The flavonoid tanetin could contribute to the anti-inflammatory properties of feverfew by inhibiting the generation of pro-inflammatory eicosanoids.

 Inhibits both cyclo-oxygenase and lipoxygenase metabolic products in vitro:

 "Contains a complex mixture of sesquiterpene lactone and non-sesquiterpene lactone inhibitors of eicosanoid synthesis of high potency." "These biochemical actions may be relevant to the claimed therapeutic actions of the herb."

 Displays antithrombotic potential in addition to its claimed benefit in fever, migraine and arthritis. Inhibits induction of human platelet aggregation by ADP, collagen, and thrombin in vitro.

 Inhibits secretory activity in blood platelets and polymorphonuclear leukocytes (PMNs). Consistently inhibits platelet aggregation but not thromboxane synthesis. "The pattern of the effects of the feverfew extracts on platelets is different from that obtained with other inhibitors of platelet aggregation and the effect on PMNs is more pronounced than has been obtained with very high concentrations of non-steroidal anti-inflammatory agents."

 Sesquiterpene lactones, which al contain alpha-methylene butyrolactone units, have the effect of inhibiting secretion of granules of serotonin and other compounds from platelets and neutrophils that contribute to the vascular pathosis of migraine.

 Dramatically reduces the number of acid-soluble sulphydryl groups in platelets in vitro at concentrations similar to those that inhibit platelet secretory activity. Feverfew itself does not induce the formation of disulphide-linked protein polymers in platelets but polymer formation occurs when aggregating agents are added to feverfew-treated platelets.
 Feverfew Extract INCI Name Chrysanthemum Parthenium Extract CAS 89997-65-9 EINECS ELINCS No 289-701-2 Tanacetum parthenium photo picture image

 Extracts inhibit anti-IgE-induced histamine release from mast cells in vitro:

 Acts as a potent inhibitor of aortic smooth muscle phospholipase(s) A2 in lab animal tissue.

 Extracts of fresh leaves cause inhibition of contraction of aortic rings from lab animals. The inhibitory effects are due to presence of -SH reactive parthenolide and other sesquiterpene alphamethylenebutyrolactones in these extracts. Extracts of dried powdered leaves are not inhibitory but themselves elicited potent and sustained contractions of aortic smooth muscle, probably because they do not contain parthenolide or butyrolactones according to a chemical-HPLC assay, "There are marked differences in the pharmacological potency and profiles between preparations from fresh and dried feverfew"; "this may relate to their lactone content."

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citations1.Feverfew,Dioscorides's Fever Reducer or febrifugia,what is the history of this pretty daisy-like flower?

last edit date:20th,June.2009.