What is Cornus fruit or Dogwood fruit and how to use it?

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Suggestions and Administrations of Dogwood Fruit.

Dogwood Fruit Extract INCI Name Cornus officinalis Fruit Extract Asiatic dogwood fruit extract Corni Fructus extract Cornus officinalis Sieb. et Zucc Fructus Corni Arillas Corni photo picture image Dosage and Administration: 6-15g; 30g in large dosage,decocted in water for and oral dose.

 Precaution and Contractindication: Difficulty in micturition

 Note: It is important to be evaluated by a health professional before taking this herb.This herb is contraindicated in cases with damp-heat or dysuria.

 Drug Interactions: Due to the diuretic action of this herb the following drug interactions are possible: increased risk of toxicity with anti-inflammatory analgesics; if hypokalemia occurs possible antagonism with antiarrhythmics and potentiation of muscle relaxants; antagonizes antidiabetic (hypoglycemic) drugs; may potentiate and/or interfere with antihypertensives; may potentiate lithium therapy; when taken with corticosteroids there is a risk for hypokalemia; may potentiate other diuretics and increase the risk of hypokalemia. Due to the antihypertensive (hypotensive) action of this herb the following interactions are possible: when taken with anesthetics an increased hypotensive effect; potentiation of antihypertensives; when taken with diuretics difficulty with diuresis and hypertension may result; antagonism of sympathomimetics.

 Dogwood fruit is warm and nourishing in property and can induceastringency, so it should not be used in cases of hyperactivity of the liver-yang, or constitutionof damp-heat or difficulty in micturition.

 Toxicity Study:Dogwood Fruit

 Acute Toxicity of Dogwood Fruit Water Extract:

 Dogwood Fruit Water Extract:LD50 >10grams/kg.cumulation coefficient>5,10 g/kg; no reratogenicity observed.Result: water extracts of dogwood fruit shows no acute toxicity and cumulative toxicity;no reratogenicity on amniote.Refference:Study on the Toxicity of the Water Extract from the Pulp of Comus.by Zhang Huizhen,Wu Yiming,Wu Yongjun,Hu Shibing,from Carcinogenesis,Teratogenesis and Mutagenesis,03,2004.

 Mutagenic Toxicity of Dogwood Fruit Water Extract:

 Test of mutagenicity on PCE,testis micronucleus, and sperm in mice of dogwood fruit.Method:PCE,micronucleus,Chromosome aberratIon test In mice testlcle ceIls and mice Sperm Malformation Test,observing effects of different dosage of dogwood fruit water saps(10 g/kg,5g/kg,2.5 g/kg) and negative control (distilled water),Active control (cyclophosphamide),test micecells mutation rate,sperum abnormality rate and PCE micronucleus rate.Result:no statistical results got from compare of above mentioned rate to negative control; but statistical results got from compare to active control,P less than 0.01.Thus come into a conclusion that dogwood fruit water extraction saps shows no damage effects on cell or chromosome levels,nor can increase PCE micronucleus rate.The matters extracted has no damage effect on the chromosome and cell levels. It provides science proof on exploiting functional health food of cornus of ficinalis sieb.et Zucc.Reference:Effect of the extraction from pulp of cornus officinalis by water on mutagenicity on PCE,testis micronucleus, and sperm in mice,.by Zhang Huizhen,Wu Yiming,Fan Qingtang,Hu Shibing,From Journal of Zhengzhou Univeristy(Medical Sciences).05,2004;Mutagenicity of the Matter Extracted from the Pulp of Cornus by Ethanol,by ZHANG Huizhen, SONG Chunhua ,YANG Jiyao,HU Shibin,WU Yiming,from R994.4;R994.6,Article ID:1004-616X(2005)03-0187-03.

 Acute Toxicity of Dogwood Fruit and Kernels:

 Dogwood fruit:LD50.Mice.Oral.>90.8 g/kg.Dogwood fruit kernel:LD50.Mice.Oral.>53.55 g/kg.

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Reference:

citations1.What is Cornus fruit or Dogwood fruit and how to use it?

last edit date:20th,June.2009.