What is Cornus fruit or Dogwood fruit and how to use it?

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Modern Research and Identification of Dogwood Fruit.

Dogwood Fruit Extract INCI Name Cornus officinalis Fruit Extract Asiatic dogwood fruit extract Corni Fructus extract Cornus officinalis Sieb. et Zucc Fructus Corni Arillas Corni photo picture image Identification of volatiles from hawthorn and flowering dogwood fruit that may be involved in host plant location by Rhagoletis fruit flies

 Chemical analyses, using Solid Phase Microextraction and GC-EAD, of head space volatiles from hawthorn and flowering dogwood fruit have resulted in the identification of chemicals that may be involved in host fruit discrimination by Rhagoletis fruit flies that infest each fruit type. Several chemicals that elicited high EAD activity are common to the two fruit types, whereas others are unique to each. The chemical analysis forms the foundation for selection of candidate odor blends for behavioral assays of odor discrimination in flies from each fruit type.

 Dogwood fruit has effects of inducing diuresis, lowering blood pressure, inhibiting the growth of Bacillus dysenteriae and Staphylococcus aureus.

 Test in vitro showed that it can kill ascitic cancer cells of the mice. In addition, it also has actions of antihistamine and weak excitation on the parasympathetic nerve.
 The fruit, without the seed, is decocted for the treatment of arthritis, fever and a wide range of other ailments.
 The stembark is astringent, antimalarial and tonic.
 The plant is antibacterial, diuretic, hypotensive and a urinary antiseptic.
 Dogwood Fruit Extract INCI Name Cornus officinalis Fruit Extract Asiatic dogwood fruit extract Corni Fructus extract Cornus officinalis Sieb. et Zucc Fructus Corni Arillas Corni photo picture image

 Cornus Officinalis has been tested in liver cancer:

 Composition of Cornus Officinalis:Cornusiin A, cornusiin B and cornusiin C, cornuside, are dimeric, monomeric and trimeric hydrolyzable tannins, loganin, morroniside, Dimethyltetrahydrofuran cis-2,5-dicarboxylate a furan derivative, gallic acid, 1,2-benzenedicarboxylic acid, butyl 2-methylpropyl ester, isopropyl myristate, anthocyanins.

 Chemoprevention against hepatocellular carcinoma of Cornus officinalis in vitro.:

 The water extracts of Cornus officinalis Sieb. et Zuce against hepatocellular carcinoma (HCC) was studied for its chemopreventive potential. Three HCC cell lines (HepG2, SK-Hep1 and PLC/PRF/5) and three leukemic cell lines (U937, K562 and Raji) were tested with XTT assay. Extracts of C. officinalis inhibited all these HCC cells and leukemic cells at a concentration of 100 microg/ml (P less than 0.05) and was dose-dependent (P less than 0.0001). P53 (P less than 0.0001) and Ras significantly affected its activity against HCC. Extracts of C. officinalis also possessed the anti-oxidant activity through free radicals scavenging activity at a concentration of 50 microg/ml (P less than 0.05). In summary, our experiment implied that C. officinalis might be a candidate for chemopreventive agent against HCC through the antioxidant and anti-neoplastic effects.

 Corni fructus as the major herb of Die-Huang-Wan for lowering plasma glucose in Wistar rats.:

 Die-Huang-Wan is a mixture of six herbs used to lower plasma glucose by increasing insulin secretion in normal rats. Die-Huang-Wan contains the herbs dioscorea (Dioscoreae rhizoma), cornus (Corni fructus), alisma (Rhizoma alismatis), holelen (Poria), rehmannia (Rehmanniae radix) and tree peony bark (Moutan radicis cortex). The present study was designed to clarify the major herb contributing to the plasma glucose-lowering action of Die-Huang-Wan in rats. A decrease in plasma glucose was not observed in Wistar rats treated with the cornus-deleted formula of Die-Huang-Wan; however, the action was retained in the other herb-deleted formulas containing cornus. In normal rats, the decrease in plasma glucose and increase in plasma insulin concentrations were dependent on the dose of cornus and were similar to those produced by Die-Huang-Wan. Treatment of Wistar rats with each of the other five herbs separately did not result in a decrease in plasma glucose. Moreover, the increase in plasma insulin or reduction in plasma glucose resulting from cornus treatment was blocked by atropine or 4-diphenylacetoxy-N-methylpiperidine methiodide mustard, indicating mediation of muscarinic M(3) receptors similar to that caused by Die-Huang-Wan. These results suggest that cornus is the major contributor to the plasma glucose-lowering action in Die-Huang-Wan in normal rats.
 Dogwood Fruit Extract INCI Name Cornus officinalis Fruit Extract Asiatic dogwood fruit extract Corni Fructus extract Cornus officinalis Sieb. et Zucc Fructus Corni Arillas Corni photo picture image

 Effect of alcohol extract of Cornus officinalis Sieb. et Zucc on GLUT4 expression in skeletal muscle in type 2 (non-insulin-dependent) diabetic mellitus rats.:

 Based on its effects of decreasing postprandial plasma glucose and increasing insulin level in non-insulin-dependent diabetic mellitus (NIDDM) rats, we studied the effects of Alcohol extract of Cornus officinalis Sieb. et Zucc on the GLUT4 expression in NIDDM model rats. CONCLUSION: This experiment demonstrated that alcohol extract of Cornus officinalis Sieb. et Zucc can increase GLUT4 mRNA and its protein expression in NIDDM rats through promoting proliferation of islet and increasing postprandial secretion of insulin and therefore accelerate glucose transport.

 Characterization, quantification, and bioactivities of anthocyanins in Cornus species.:

 Cornus mas, Cornus officinalis, Cornus controversa, and Cornus kousa (Cornaceae) bear edible fruits that are consumed in parts of Europe and Asia. This study undertook the investigation of the presence and levels of anthocyanins in the fruits of these Cornus species by HPLC. The anthocyanins present in Cornelian cherries, C. mas, are delphinidin 3-O-beta-galactopyranoside (1), cyanidin 3-O-beta-galactopyranoside (2), and pelargonidin 3-O-beta-galactopyranoside (3). C. officinalis contains only anthocyanins 1-3, similar to C. mas, but in different proportions. However, C. controversa contains anthocyanins 1-3 among other anthocyanins, but Chinese dogwood, C. kousa, did not contain 1-3. The contents of pure anthocyanins 1, 2, and 3 in 1 kg of fresh fruits of C. mas, C. officinalis, and C. controversa were 280, 1079, and 710 ppm; 11, 77, and 230 ppm; and 600, 1000, and 700 ppm, respectively. In cyclooxygenase (COX)-I and -II enzyme inhibitory assays, anthocyanins 1-3 (all 40 microM) showed activities of 9.2 and 11.7%; 7.6 and 12.4%; and 5.3 and 7.8%, respectively, compared to Naproxen (54.3 and 41.3%; 10 microM), ibuprofen (47.5 and 39.8%; 10 microM), Celebrex (46.2 and 66.3%; 1.67 ppm), and Vioxx (23.8 and 88.1%, 1.67 ppm). In the antioxidant assay, anthocyanins 1-3 (all 40 microM) showed activities of 70.2, 60.1, and 40.3%, respectively. At 10 microM concentration, commercial synthetic antioxidants tert-butylhydroquinone, butylated hydroxytoluene, butylated hydroxyanisole, and vitamin E gave 83.2, 79.7, 82.1, and 10.2% of antioxidant activity, respectively.

 A substance isolated from Cornus officinalis enhances the motility of human sperm:

 The effects of Chinese herb, Cornus officinalis, on the motility of human sperm was studied. An aqueous extract was prepared from the dried fruits of the herb and used in this study.

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citations1.What is Cornus fruit or Dogwood fruit and how to use it?

last edit date:20th,June.2009.