Petasites hybridus,butterbur root,from tradition to modern uses.

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Phytochemicals and Constituents.

Petasites hybridus Extract INCI Name Petasites Hybridus Extract CAS:90082-63-6 EINECS ELINCS No 290-153-1 Butterbur root extract Petasin photo picture image Extracts of Petasites hybridus are prepared from the rhizomes, roots, and leaves.

 The main active constituents are two sesquiterpenes, petasin and isopetasin. Petasin is responsible for the antispasmodic properties of the plant by reducing spasms in smooth muscle and vascular walls, in addition to providing an anti-inflammatory effect by inhibiting leukotriene synthesis. Prostaglandins are important mediators in the inflammatory process and isopetasin's positive impact on prostaglandin metabolism contributes to the effectiveness of Petasites extracts. Extracts of the plant also contain volatile oils, flavonoids, tannins, and pyrrolizidine alkaloids. As these alkaloids are believed to be toxic to the liver and carcinogenic in animals, extracts are available in which the pyrrolizidine alkaloids have been removed.

 Effective content: tussilagone,C23H34O5; rutin,C27H30O16,0.36%; hyperoside,C21H20O12,0.28%.
 Petasites hybridus Extract INCI Name Petasites Hybridus Extract CAS:90082-63-6 EINECS ELINCS No 290-153-1 Butterbur root extract Petasin photo picture image

 The main active ingredients of petasites hybridus are two sesquiterpenes, petasin and isopetasin. Research has shown that petasin possesses anti-spasmodic properties that help to reduce spasms in smooth muscle and vascular walls. Petasin has also been found to be a powerful anti-inflammatory agent that inhibits synthesis of leukotrienes that act as potent pro-inflammatory agents in blood vessel walls, causing bronchoconstriction in asthma.The second active ingredient, isopetasin, has also been found to reduce inflammation by modulating prostaglandin metabolism. Together these ingredients have an antispasmodic effect on vascular walls, with a marked affinity for cerebral blood vessels.

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citations1.Petasites hybridus,butterbur root,from tradition to modern uses.

last edit date:23th,June.2009.