Petasites hybridus,butterbur root,from tradition to modern uses.
Article Content:
- .Botanical Data Info of Butterbur Root.
- .Petasites hybridus: Introduction.
- .Phytochemicals and Constituents.
- .Mechanisms of Action.
- .Migraine Traditional Treatment and Herbal Substitution.
- .Medical uses for Petasites.
- .Suggestions and Administrations.
- .Petasites research petasites for migraine petasites.
- .Petasites Research Update.
Migraine Traditional Treatment and Herbal Substitution.
Migraine:
Migraines strike women three times as frequently as men, affecting 5% of men and 17% of women in the United States. In direct medical costs and lost productivity, the annual cost in the United States is estimated to exceed $17 billion. In spite of these numbers, according to the International Headache Society many migraines go unrecognized and undertreated due largely to the fact that there are no recognized biological markers to confirm the diagnosis.
While the exact cause of migraine is not fully understood, migraines can be triggered by internal and external factors, such as stress, anxiety, food allergies, hormones and environmental changes, such as light, heat and altitude. When triggered, the nervous system responds with increased serotonergic activity in the brain, vasodilation of the extra-cranial blood vessels, and concomitant vasoconstriction of the intra-cranial blood vessels.
Migraine Symptoms:
Unlike tension headaches, migraines are a full-blown neurologic disorder characterized by recurrent attacks of headache that, if not successfully treated, can last anywhere from 2 to 72 hours. Migraine pain is usually unilateral, appearing as a throbbing, pounding pain on only one side of the head. During different phases of a migraine attack, pain can move from one part of the head to another, or radiate down into the neck and the shoulders. Skin hypersensitivity, including scalp irritation and tenderness, also occur frequently during a migraine attack.
Migraine sufferers often experience nausea and vomiting accompanied by a pronounced and extreme sensitivity to light (photophobia), sounds (phonophobia) and odors (osmophobia). In severe attacks, even normal activities such as standing or walking can intensify pain to the point where normal function is completely disrupted.
Migraine Aura:
Approximately 20% of all migraine sufferers experience visual disturbances that are referred to as the migraine aura. In addition to alterations in perception of light, sound and smell, aura can include bizarre visual distortions such as blurry vision, spots, flashing lights, wavy lines, flashing lights, and/or partial loss of sight. Other symptoms may include vertigo, tingling or numbness of the face or extremities, auditory hallucinations, difficulty or confusion when forming words, and impaired hearing. Some patients even have the aura without the headaches.
Standard Migraine Treatment:
Standard treatments aim to control symptoms by calming sensitive nerve pathways and reducing the inflammatory response while preventing future attacks. As with tension headaches, some individuals find that very mild migraine attacks can be treated with standard analgesics such as aspirin, acetaminophen, ibuprofen and naproxen. These drugs, in addition to their potential gastrointestinal side effects, have been shown to increase risk of rebound (medication-induced) headaches. Combination medications such as acetaminophen with codeine, aspirin with codeine and caffeine, and aspirin with butalbital and caffeine (with or without codeine) are sometimes used. However, overuse of combination medications is one of the most prominent causes of rebound headache, which is the leading form of chronic daily headache.
5-HT1 Receptor Agonists:
Sumatriptan, a selective 5-hydroxy-triptamine 1 (5-HT1) receptor agonist, has been shown more effective than placebo in treating moderate to severe migraines (50-80% versus 20-40%) when administered by subcutaneous injection. Reported side effects include tightness in the chest, chest pain, pain in the throat, tingling in the head or limbs, nausea, and a high rate (44%) of migraine recurrence within 24 hours.
Dihydroergotamine (DHE), a nonselective 5-HT1 receptor agonist, has also been shown effective in relieving headache when used subcutaneously, intramuscularly or intravenously, but side effects are similar to those of sumatriptan.
Ergotamine has also been used for many years to treat migraine, but meta-analysis has demonstrated little benefit from oral dosing.Side effects of ergotamine resemble those of DHE, but nausea is usually more severe.
Other migraine medications include:
Beta-blockers (Propranolol)
Tricyclic anti-depressants (Amitriptyline)
MAO inhibitors (Phenelzine)
Adrenergic blockers (Clonidine)
Serotonin antagonists (Cyproheptadine)
Calcium channel antagonists (Verapamil)
Anticonvulsants (Phenytoin)
Butorphanol nasal-spray (Stadol)
As with the previous medications, side effects of these medications are substantial. In the case of beta-blockers, they are contraindicated for patients with asthma, chronic obstructive pulmonary disease, insulin-dependent diabetes mellitus, heart failure, or peripheral vascular disease. Calcium-channel blockers, which can take several months to become effective, are contraindicated in pregnancy and in patients with hypotension, congestive heart failure, arrhythmias or depressive illness.
Herbal Treatments:
A course of therapy with Butterbur petasin extract has been scientifically proven to be beneficial in the alleviation of hayfever symptoms.
Butterbur comes from the Asteraceae family, and is a fleshy, creeping plant with a short root.
Extracts from the leaves and roots have been used, since ancient Greek times, as an anti-inflammatory, a smooth muscle relaxant (anti-spasmodic) and pain reliever (analgesic).
These traditional uses are supported by modern science.
Butterbur petasin's main active ingredients are petasin and isopetasin, with the highest concentrations occurring in the root.
There are two types of Butterbur plant, both looking identical yet very different. One kind of Butterbur contains petasins (Butterbur Petasin) and the other contains only trace amounts (Butterbur Furan). When choosing a brand of Butterbur ensure that it is made from Butterbur Petasin and that it is standardised to at least 7.5mg of Petasin and isopetasin per 50mg butterbur.
Their effects are reported to be:
Spasmolytic: reducing spontaneous activities and spasms in smooth muscle, including vascular walls.
Anti-inflammatory: acting on the arachnidonic acid cycle by inhibiting inflammatory leukotriene synthesis.
There are no known drug interactions with Butterbur petasin extract.
Butterbur petasin should not be used during pregnancy and breast feeding.
Petasites Extract Reduces Incidence of Migraine:
Researchers in Germany conducted a randomized, placebo-controlled, double-blind clinical study using a standardized extract of petasites (60 patients suffering from headaches with and without aura randomly received either 50 mg of a standardized petasites extract or placebo, twice daily for 12 weeks. At the conclusion of the test the researchers found that, compared to placebo, petasites hybridus significantly reduced the frequency of migraine attacks and days with migraine per month, as well as the frequency of accompanying symptoms. Compared to baseline, petasites hybridus reduced the frequency of attacks by 46% after 4 weeks, 60% after 8 weeks and 50% after 12 weeks of treatment (placebo group: 24%, 17% and 10%, respectively).
The researchers also found that the extract reduced the total number of migraine days.
Of particular interest was the finding that patients who entered the study reporting at least three migraine attacks per month showed the most pronounced reduction in events. Patients also reported significant alleviation of intensity of migraine pain, leading researchers to conclude that petasites extract is most effective in reducing migraine in patients who suffer the most from frequent severe attacks.
Conclusions:
Standardized extract of Petasites hybridus offers a new option for migraine sufferers.
Petasites hybridus extracts is effective in reducing the number of days with migraines per month, in decreasing migraine-associated symptoms, and in reducing both the duration and intensity of migraine pain.
Petasites extract has a history of excellent tolerance, and no adverse side effects have been reported. It should be noted that it is important to take Petadolex on a daily basis for maximum effectiveness.
Reference:
1.Petasites hybridus,butterbur root,from tradition to modern uses.
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