The crude drug extracts caused transient hypotensive effect which is partly inhibited by atropine. The gluco alkaloid, saponin and resin fraction increased the force of contraction of isolated frog's heart and caused gradual rise in blood pressure levels. The alcoholic leaf extract, resinous and crystalline fi-acons caused contraction of dog tracheal chain while the glucoalkaloid and alcoholic stem extract after initial potentiation caused refractoriness to the constrictor responses of acetylcholine and histamine. Histamine releasing effects have been shown.
Latin name: Leptadenia reticulata
Part used: Whole plant
Properties: It is cooling, eye tonic, nutritive & aphrodisiac drug.
Clinical uses: It is known to help in eye diseases, seminal-debility & general weakness
L.reticulata is a much-branched twining shrub. The bark is yellowish brown, corky, deeply cracked; the leaves are ovate-cordate, coriaceous glabrous above, more or less finely pubescent beneath; the flowers are in many-flowered cymes, greenish yellow; the follicles are sub-woody and turgid.
It grows in the sub-Himalayan tracts of Punjab, U.P. and throughout the Deccan Peninsula up to an altitude of 900 m, in India.
Phytochemicals and Principal Constituents:
The plant contains a triterpenoid, leptadenol (C30H50O). It also contained n -triacontane, cetyl alcohol, Beta-sitosterol, beta-amyrin acetate, lupanol 3-O -diglucoside and leptidin.
Pharmacology and Clinical Studies:
A number of studies have been carried out on the galactagogue property of the plant in laboratory animals. Studies on the lactogenic property of L.reticulata were carried out on lactating rats using pup weight, body weight of mother rats, and histopathological study of lactating mammary gland, as well as the secretory rating, parenchyma percentage, estimation of glycogen content (of the abdominal mammary glands) and the protein content (of the pectoral mammary glands) as parameters. While both stigmasterol and the ether fraction of L.reticulata showed lactogenic effect, as assessed by all these parameters, stigmasterol was found to be more potent2.A herbal preparation with L.reticulata as one of the nine constituents is said to exert beneficial effects on the gametogenic and androgenic functions of the testes of animals. It showed anabolic cum androgen like activity as evidenced by the dose related growth of the ventral prostate and the systemic increase in the weights as well as the secretions of the accessory sex organs of castrated adult mice.
Clinical studies:
The lactogenic/galactagogue effect of L.reticulata has been clinically assessed by many investigators. These studies have been mainly carried out on the commercial preparation of Leptaden.
Toxicology:
On acute toxicity studies, L.reticulata (aqueous extract) and leptaden administered orally for three alternate days, and three consecutive days to rats, were safely tolerated up to a dose of 3.125 g/kg. An increase in dose led to an increase in mortality. Post mortem, subcutaneous peticheal hemorrhage was noted, whilst the liver, kidney and heart showed no apparent change.
Indications and Application:
The plant is stimulant and restorative and shows anti-bacterial activity against gram-positive and gram-negative bacteria.
The crude drug extracts caused transient hypotensive effect which is partly inhibited by atropine. The gluco alkaloid, saponin and resin fraction increased the force of contraction of isolated frog's heart and caused gradual rise in blood pressure levels. The alcoholic leaf extract, resinous and crystalline fi-acons caused contraction of dog tracheal chain while the glucoalkaloid and alcoholic stem extract after initial potentiation caused refractoriness to the constrictor responses of acetylcholine and histamine. Histamine releasing effects have been shown.
Roots are one of the constituents of Dasamulasava. The plant is useful in fever, cough, asthma, constipation. Seeds are used as diuretic. The juice of the berries is reported to he useful in sore throat. A decoction of plant is used in gonorrhoea and it also said to promote conception in females. A. clinical trial showed kantakari to be useful in cases of Kasa Roga (cough) and also in Tamakswasa (bronchial asthma). The plant has a definite effect in diminishing the intensity of cough and dyspnoea.
Scientific References:
1.Leptadenia reticulata and Its Extract...
Claims & Warning:
Claims: Information this web site presented is meant for Nutritional Benefit and as an educational starting point only, for use in maintenance and promotion good health in cooperation with a common knowledge base reference...Furthermore,it based solely on the traditional and historic use or legend of a given herb from the garden of Adonis. Although every effort has been made to ensure its accurate, please note that some info may be outdated by more recent scientific developments......
Pharmakon Warning: The order of knowledge is not the transparent order of forms and ideas,as one might be tempted retrospectively to interpret it; it is the antidote....(Dissemination,Plato's Pharmacy,II.The Ingredients:Phantasms,Festivals,and Paints;138cf. Jacques Derrida.).
And as it happens,the technique of imitation,along with the production of the simulacrum,has always been in Plato's eyes manifestly magical,thaumaturgical:......and the same things appear bent and straight to those who view them in water and out,or concave and convex,owing to similar errors of vision about colors, and there is obviously every confusion of this sort in our souls.And so scene painting (skiagraphia) in its exploitation of this weakness of four nature falls nothing short of witchcraft (thaumatopoia), and so do jugglery and many other such contrivances.(Republic X,602c-d;cf.also 607c).
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Serie No.:P054.Basic Data Sheet Download
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seminal trace...Leptadenia reticulata.Jeevanti.Extract Jeevanti,Jivanti,Jivani,Madhusrava,Dori....
Basic Botanical Info of Jeevanti:
Clinical studies:
Scientific References:
Claims & Warning:
