Aloe origned from arab words allcoh,a traditional herb from ancient Egypt,its effects identified by people of ancient Egypt and called as Secret Plant.

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Administration and Suggestions:Aloe.

Curacao aloes Extract INCI Name Aloe Barbadensis Extract CAS 85507-69-3 EINECS ELINCS No 287-390-8 aloes extract Aloe vera extract Aloe barbadensis Miller Aloe ferox Mille Chirukattali extract photo picture image How much to take:Preparation and Dosage:

 For constipation:  a single 50-200 mg capsule of aloe latex can be taken each day for a maximum of ten days. Topically for minor burns, the stabilized aloe gel is applied to the affected area of skin three to five times per day; Treatment of more serious burns should only be done after first consulting a health care professional. For internal use of aloe gel, 30 ml three times per day is used by some people.

 Regulatory Status:  GSL Schedule 1. Maximum dose 100mg; short-term use only
 Aloes:  50-200mg, single dose at bedtime
 Concentrated Compound Aloes Decoction B.P.C (1949):  4-15ml
 Aloes Extract B.P.C 1949): 60-250mg
 Aloes Tincture B.P.C (1949):  1:40 in 45% alcohol, 2-8ml

 Additional Comments:  The Aloe originates from tropical Africa, where related species are used as an antidote to poison arrow wounds. The Greeks and Romans used the gel for wounds. Aloes was a favoured purgative during the Middle Ages. It is used as a flavouring ingredient in low concentrations and aloe vera gel is an ingredient of many cosmetic preparations and sun creams. It is used as a paint to discourage nail biting due to its intensely bitter taste. Other species are also used medicinally; these include Aloe ferox (Mill.) or Cape Aloes, and Aloe perryi (Baker) or Socotrine or Zanzibar Aloes. Cultivated varieties are grown mainly for their reduced anthraquinone content.

 Side Effects and Cautions:

 Except in the rare person who is allergic to aloe, topical application of the gel is harmless. For any burn that blisters significantly or is otherwise severe, medical attention is absolutely essential. In some severe burns and wounds, aloe gel may actually impede healing. Laxative preparations, if used for more than ten consecutive days, can aggravate constipation and cause dependency. Constipation that does not resolve within a few days of use of laxatives may require medical attention.

 Caution:  Overdosage can cause gastritis, diarrhoea and nephritis. As Aloes stimulates uterine contractions, it should be avoided during pregnancy. Also, because it is excreted in breast milk, it should be avoided during lactation as it may be purgative to the child. It should also be avoided in kidney disorders, haemorrhoids or irritable bowel conditions. Aloes should be taken for a maximum of 8-10 days.

 The topical use of aloe gel or aloe gel products does not usually produce adverse reactions or side effects. However, there are reports of skin burning following dermal abrasion for removal of acne scars. Rare instances of contact dermatitis (rash) have also been reported. Taking more than the recommended dose of aloe juice may produce a laxative effect. You can get too much of a good thing.

 If you are using oral corticosteroids, such as beclomethasone, methylprednisolone, or prednisone, it is important not to overuse or misuse Aloe vera juice. A potassium deficiency can develop, and you may experience toxic effects from the medication.

 Although it is removed, in practice Aloe vera juice may sometimes still contain tiny quantities of the laxative compound found in aloe latex. Should you begin to have cramps or diarrhea do not ingest any more of the juice.

 Allergies to aloe vera are very rare. Yet any food can be a potential allergen. Test a small amount on the inner arm to see if any reaction takes place. If no irritation on the skin is observed then it is generally tolerated. If ingestion causes diarrhea, then reduce the amount you ingest, increasing use slowly over several days until the desired amount is tolerated.

 Precautions:

 Aloe vera gel is generally safe for topical use, but it is best to apply it to a small area first to test for possible allergic reaction. Stinging and generalized dermatitis may result in individuals who are sensitive to it. The vast majority of the warnings apply only to products containing anthraquinones, such as aloin and barbaloin (as well as the numerous others), which are found in the latex layer of the plant. Aloe vera latex should not be used internally by women who are pregnant or lactating, or by children. This product can cause abortion or stimulate menstruation. It may pass into the milk of breastfeeding mothers. People who have abnormal kidney function, heart disease, or gastrointestinal diseases are best advised to avoid any product containing Aloe vera latex or anthraquinones. Prolonged, internal use in high doses may produce tolerance so that more is required to obtain the laxative effect. Be aware of the possibility that any Aloe vera product for internal use that is supposed to contain only the gel portion can become contaminated by the anthraquinones of the latex layer. For this reason, people who have a contraindication for using Aloe vera latex should use caution when taking an Aloe vera gel product internally.

 Side effects:

 Internal use of Aloe vera latex may turn the urine red, and may also cause abdominal pain or cramps when products containing anthraquinones are consumed.

 Interactions:

 Chronic internal use of products containing Aloe vera latex may increase the likelihood of potassium loss when used concomitantly with diuretics or corticosteroids. It may possibly compound the risk of toxicity when used with cardiac glycosides (both prescription and herbal types) and antiarrhythmic drugs. Absorption of other oral medications can be decreased. Aloe vera latex should not be used with other laxative herbs, which may also lead to excessive potassium loss.

 Internal use of Aloe vera gel can cause changes in blood sugar, so diabetics should monitor blood glucose levels during use, particularly if insulin or other pharmaceuticals are being used to control hyperglycemia.

 Topical Aloe vera may enhance the effect of topical corticosteroids and allow a reduction in the amount of the steroid being used.

 Safety and Toxicity:Aloe and Its Contents

 Toxicity:Aloe Polysaccharides

 Acute Toxicity.LD50,Lethal dose,50 percent death,Rat.Oral.>5g/kg;Mice.Oral.>10 g/kg.Generally very safe.

 Sub-acute Toxicity:Mice.Oral dose at different dose:1g/kg,1.5g/kg,2g/kg,5g/kg/d,continuous for 14 days,All dose groups were observed abdominal expansion, abnormal breathing, reduced defecation;1g/kg,2g/kg groups 1 each,5g/kg group 2 died because block of gastric emptying.Dog taken 1.5g/kg/d no negative effects observed.

 Subchronic Toxicity:SD Rat.Oral.different dosages at 0.2g/kg/d,0.65g/kg/d,2g/kg/d,continuous 6 months,dog oral taken different dosages at 0.1g/kg/d,0.4g/kg/d,1.5g/kg/d,continuous 90 days,Blood, serum and urine, the results were in the normal range, gross anatomy and pathology examinations of the subjects and not the pathological damage.

 Mutagenic Data:800ul/plate,add S9/no add S9,Result:Ames negative.

 Chronic Toxicity:no report on 2 years cancer test on animals.

 Safety Dose:According to 100 times safety factor,Aloe Polysaccharides safety daily dosage:1.2 grams.

 Toxicity:Aloe Powder

 Acute Toxicity.LD50,Lethal dose,50 percent death,Mice.Oral.>10 g/kg.Generally very safe.

 Mutagenic Data:Ames test 5000ug/plate,negative,2.5,5,10 g / kgBW mouse bone marrow micronucleus, sperm abnormality test negative

 30 days feed test:8.1g/kgBW weight slower growth, the ratio of kidney/body weight increased.

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citations1.Aloe origned from arab words allcoh,a traditional herb from ancient Egypt,its effects identified by people of ancient Egypt and called as Secret Plant.

last edit date:6th,July.2009.