Citrus aurantium and Synephrine.

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applications dot Pharmacological and clinical research of Citrus aurantium.

Bitter Orange Extract INCI Name Citrus Aurantium Amara Extract CAS 72968-50-4 EINECS ELINCS No 277-143-2 Synephrine Seville Orange Zhi Shi Naranja Agria Neroli Petitgrain Seville Orange Citrus Bergamia Citrus Bigaradia Citrus Vulgaris photo picture image Effect on the uterus: decoctions of Fructus Citri seu Ponciri Immaturus (Zhi Shi) from three different provinces (Sichuan, Jiangxi, and Hunan) inhibited uterus specimens from mice and stimulated those from rabbits, as well as stimulating that organ in situ. These findings were the same for both pregnant and nonpregnant animals. An alkaloid-like substance from Fructus Ponciri Trifoliatae (Zhi Shi) has a definite contractile effect on uterus specimens from rabbits, especially when under the contractile influence of oxytocin. When alkaloids were removed from the herb, it produced a relaxing effect on the tissues.

 Effect on intestines: Fructus Aurantii Immaturus (Zhi Shi) from three different provinces had an inhibitory effect on intestinal specimens and in situ intestines in mice and rabbits. The effect varied with the dosage, and in some cases very small doses (on the order of 1:10,000) showed a transient inhibition followed by an increase in both the intensity and frequency of peristalsis.

 Cardiovascular effect: small doses of Fructus Aurantii Immaturus (Zhi Shi) have a stimulatory effect on frog heart specimens, while large doses are inhibitory. Intravenous administration of decoctions of this herb to anesthetized dogs leads to a marked rise in blood pressure. It has been noted that there was no reflex drop in blood pressure after the herb had worn off. While the a receptors appeared to be affected, leading to vasoconstriction, there was actually an increase in coronary, brain, and renal blood flow. This may be due in part to the positive inotropic effects leading to an increase in stroke volume. There was a reduction in blood flow through the femoral arteries. Experiments on animals have shown a low incidence of mild supraventricular arrhythmias from intravenous use of this herb. This, in addition to the findings noted above, has led some researchers to conclude that this herb may have some use in treating cardiogenic shock."

 Functions and clinical use: Breaks up Stagnant Qi and reduces Accumulations; used for epigastric or abdominal pain and distension or indigestion with Focal Distension or gas. Directs the Qi downward and moves stool: frequently used for abdominal pain and constipation caused by Accumulation and Stagnant Qi. Cautions and contraindications: Use cautiously during pregnancy or in any case where the Normal Qi is weak. Use cautiously in patients with Cold Deficient Stomach.

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reference dot Reference:

citations 1.Citrus aurantium and Synephrine.
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last edit date:10th,Mar.2010.
 Available Product
  • Name:Bitter Orange Extract
  • Serie No:P090
  • Specifications:Synephrine 5%~98%HPLC.
  • INCI Name:CITRUS AURANTIUM AMARA EXTRACT
  • EINECS/ELINCS No.:277-143-2
  • CAS:72968-50-4
  • Chem/IUPAC Name:Citrus Aurantium Amara Extract is an extract of the fruit of the bitter orange, Citrus aurantium amara, Rutaceae
 Supplying Conditions

Bitter Orange Extract INCI Name Citrus Aurantium Amara Extract CAS 72968-50-4 EINECS ELINCS No 277-143-2 Synephrine Seville Orange Zhi Shi Naranja Agria Neroli Petitgrain Seville Orange Citrus Bergamia Citrus Bigaradia Citrus Vulgaris photo picture image.
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