Mechanism of Action Category: Protects against free radical injury in vivo;Inhibits hydroxyl and peroxyl radicals;Increases plasma and LDL polyphenols;Inhibits brain monoamine oxidase in vivo;

Analysis Method,differentiation of MDidea Transresveratrol.

Method Abstract:Sample Ultrasonic Extracted with methanol, separated by HPLC, use standard material of resveratrol as external standard, calculate concentration of resveratrol in Sample by External Standard Method.(Note:Method for Analysis Available For direct Bulk Order Buyers.)
Standard Sample Suggest MDidea Group:Transresveratrol 99.99%
(Optional Standard Material Sigma:Transresveratrol 99.99%)
Cas Number: 510-36-0
Chemical Name Identification: 3,5,4'-trihydroxy-trans-stilbene
Differentiation:MDidea Transresveratrol no any cis isomer content.
Standard Name Express:[Transresveratrol(3,5,4'-trihydroxy-trans-stilbene)] as Polygonum cuspidatum P.E.
Formula / M.W.:C14H12O3/228.2
Physical State:Solid, Powder
Color:Off white
Melting Point (C):253-255
Octanol-Water Partition Coefficient (LogP):3.139~.343
pKa (of the most acidic H-donor): 9.14~.20
Solubility:Solublein diethyl ether, Chloroform,Alcohol ,Acetone, Etc.
Solubility in Water (mol/L) <0.01
Remark Resveratrol and its Metabolism and Bioavailability:

Although trans-resveratrol appears to be well-absorbed by humans when taken orally, its bioavailability is relatively low due to its rapid metabolism and elimination. When healthy men and women took an oral dose of 25 mg of trans-resveratrol, only traces of the unchanged resveratrol were detected in plasma (blood), while plasma concentrations of resveratrol metabolites peaked 30-60 minutes later at concentrations around 2 micromoles/liter.
The bioavailability of resveratrol from grape juice, which contains mostly glucosides of resveratrol (piceid) may be even lower than that of trans-resveratrol. Information about the bioavailability or resveratrol in humans is important because much of the basic research on resveratrol has been conducted in cultured cells exposed to unmetabolized resveratrol at concentrations that are often 10-100 times greater than peak concentrations observed in human plasma after oral consumption.
Although cells that line the digestive tract are exposed to unmetabolized resveratrol, research in humans suggests that other tissues are exposed primarily to resveratrol metabolites. Little is known about the biological activity of resveratrol metabolites, and it is not known whether some tissues are capable of converting resveratrol metabolites back to resveratrol.